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Updated: Jan 16, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

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Published on: October 6, 2016

Home-based EXergames To impRovE cognitive function in MUltiple Sclerosis (EXTREMUS).

Luca Prosperini¹, Andrea Tacchino², Serena Ruggieri³

¹Department of Neurosciences, San Camillo Forlanini Hospital, Roma, Italy luca.prosperini@gmail.com.

Journal of Neurology, Neurosurgery, and Psychiatry

|October 1, 2025

Summary

This summary is machine-generated.

Home-based exergames show promise for improving cognitive and motor functions in multiple sclerosis (MS) patients with processing speed deficits. However, their non-inferiority to cognitive training was not established, and benefits were not sustained long-term.

Keywords:

multiple sclerosis

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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

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Published on: January 29, 2016

Area of Science:

Neurology
Rehabilitation Medicine
Digital Health

Background:

Multiple sclerosis (MS) frequently causes disabling motor and cognitive dysfunctions, particularly impaired processing speed, which are difficult to manage.
Exergames present a potential home-based intervention for addressing these MS-related impairments.

Purpose of the Study:

To evaluate the efficacy of exergames as a standalone treatment for individuals with MS and impaired processing speed.
To compare the effectiveness of exergames against adaptive cognitive training and a sham intervention.

Main Methods:

A three-arm, randomized, rater-blinded, sham-controlled trial involving 102 participants with MS and impaired processing speed.
Participants were assigned to 8-week home-based exergames, adaptive cognitive training (COGNI-TRAcK), or sham intervention.
Primary outcome was the Symbol Digit Modalities Test (SDMT), with assessments at 8 and 16 weeks post-randomization.

Main Results:

Both exergames and COGNI-TRAcK significantly improved SDMT scores compared to the sham intervention at 8 weeks.
Non-inferiority of exergames to COGNI-TRAcK on SDMT was inconclusive.
Exergames also improved executive function, balance, and fatigue, but these effects diminished by week 16.

Conclusions:

Home-based exergames can be a viable standalone approach to enhance specific cognitive and motor deficits in MS.
Evidence for the non-inferiority of exergames compared to working memory training remains insufficient.
Further research is needed to understand the long-term sustainability of exergame benefits in MS management.