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Low-dose colchicine for management of coronary artery disease

Abhayjit Singh1, Vikas Sunder2, Leslie Cho3

  • 1Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH singha18@ccf.

Cleveland Clinic Journal of Medicine
|October 1, 2025
PubMed

Insights

Low-dose colchicine shows promise for managing atherosclerotic cardiovascular disease by targeting inflammation. This review explores its history, clinical data, and practical use in cardiovascular care.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Pharmacology

Background:

  • Cardiovascular disease is a major global health burden.
  • Inflammation is implicated in atherogenesis, but anti-inflammatory treatments show variable clinical outcomes.
  • Low-dose colchicine is emerging as a potential therapeutic agent for atherosclerotic cardiovascular disease.

Purpose of the Study:

  • To review the historical use of colchicine as an anti-inflammatory agent.
  • To analyze clinical trial data evaluating colchicine for atherosclerotic cardiovascular disease management.
  • To discuss the practical application and considerations of low-dose colchicine in clinical practice.

Main Methods:

  • Literature review of historical anti-inflammatory uses of colchicine.
  • Systematic review and meta-analysis of randomized controlled trials on colchicine for atherosclerotic cardiovascular disease.
  • Synthesis of data on efficacy, safety, and patient selection for colchicine therapy.

Main Results:

  • Colchicine has a long history as an anti-inflammatory medication.
  • Recent clinical trials demonstrate that low-dose colchicine can reduce cardiovascular events in patients with atherosclerotic cardiovascular disease.
  • The benefits appear consistent across various patient subgroups, though further research is ongoing.

Conclusions:

  • Low-dose colchicine represents a novel anti-inflammatory treatment strategy for atherosclerotic cardiovascular disease.
  • Its efficacy in reducing cardiovascular events warrants consideration in patient management.
  • Practical guidelines for its use are essential for widespread clinical adoption.

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