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Updated: Jan 16, 2026
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
10.8K
How structural variation shapes the cancer epigenome.
Signe MacLennan1, Marco A Marra2
1Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada; Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.
Trends in Cancer
|October 1, 2025
Summary
Cancer arises from genomic changes. Epigenetic disruptions and structural variations (SV) interact, influencing cancer development and progression. This review covers technologies and research on SV and the epigenome in cancer.
Area of Science:
- Oncology
- Genomics
- Epigenetics
Background:
- Cancer develops through genomic alterations leading to malignant properties.
- Epigenetic disruptions, affecting genome interpretation without altering sequence, are key in cancer.
- The interplay between structural variation (SV) and epigenetics in cancer is a growing research area.
Purpose of the Study:
- To review technological advances for simultaneous genome and epigenome profiling in cancer.
- To highlight recent research on the relationship between SV and the epigenome in cancer.
Main Methods:
- Review of current technologies for cancer genome and epigenome analysis.
- Synthesis of recent scientific literature on SV-epigenome interactions in malignancy.
Main Results:
- Technological advancements enable integrated analysis of genomic and epigenetic changes.
- Emerging research reveals complex interactions between SV and epigenetic modifications in cancer progression.
Conclusions:
- Understanding the SV-epigenome axis is crucial for deciphering cancer development.
- Future research directions involve leveraging new technologies to explore these interactions further.
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