Apolipoprotein A2 as Protection Against Increased Mortality After Aortic Aneurysm Repair.

Area of Science:

• Cardiovascular Medicine
• Biomarker Discovery
• Aortic Aneurysm Research

Background:

• Prognosis for aortic aneurysm (AA) patients with comorbidities is poor, necessitating reliable mortality biomarkers.
• Apolipoprotein A2 (ApoA2), a high-density lipoprotein cholesterol (HDL-C) component, has unclear prognostic value for all-cause mortality.

Purpose of the Study:

• To investigate the prognostic significance of Apolipoprotein A2 (ApoA2) levels in predicting mortality after surgical repair of aortic aneurysms (AA).

Main Methods:

• Measured ApoA2 levels in 203 patients undergoing surgical repair for AA.
• Analyzed mortality events over a median follow-up of 3.5 years.
• Utilized multivariate Cox analysis to identify independent predictors of mortality.

Main Results:

• Patients who experienced mortality events had significantly lower ApoA2 levels compared to survivors (P < 0.001).
• ApoA2 was inversely correlated with age, BNP, CRP, fibrinogen, and positively with eGFR.
• ApoA2, reduced eGFR, COPD, and thoracic AA were identified as independent mortality predictors.

Conclusions:

• Apolipoprotein A2 (ApoA2) serves as a potential biomarker for predicting long-term mortality in patients with aortic aneurysm (AA) post-surgical repair.
• Incorporating ApoA2 levels enhances the discriminative ability of existing risk factors for mortality prediction.
• ApoA2 may improve risk stratification in the high-risk population of AA patients.