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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Updated: Jan 16, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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[Clonal hematopoiesis].

Kenichi Yoshida1

  • 1Division of Cancer Evolution, National Cancer Center Research Institute.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

Clonal hematopoiesis, the expansion of blood stem cells with mutations, is common in aging adults. It can lead to blood cancers, cardiovascular diseases, and other cancers over decades.

Keywords:
Clonal hematopoiesisDriver mutationsGenetic background

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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Area of Science:

  • Hematology
  • Genetics
  • Oncology

Background:

  • Clonal hematopoiesis involves hematopoietic stem cell expansion and driver gene mutations.
  • It is an inevitable consequence of aging due to accumulating somatic mutations.
  • Identified driver genes are often shared with hematological malignancies.

Purpose of the Study:

  • To summarize the current understanding of clonal hematopoiesis.
  • To highlight its association with aging and cancer development.
  • To discuss its broader implications in non-hematological diseases.

Main Methods:

  • Literature review of clonal hematopoiesis research.
  • Analysis of driver gene mutations in hematopoietic stem cells.
  • Examination of the time course from mutation acquisition to disease onset.

Main Results:

  • Clonal hematopoiesis is prevalent in elderly individuals.
  • A latency period of approximately 30 years exists between initial mutation and cancer onset.
  • Genetic background influences clonal hematopoiesis initiation and progression.

Conclusions:

  • Clonal hematopoiesis is linked to hematological malignancies.
  • It also contributes to cardiovascular diseases and solid tumors.
  • Targeted therapies for driver mutations are a future prospect.