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Related Concept Videos

Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

2.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Related Experiment Video

Updated: Jan 16, 2026

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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[Coagulation function tests: principles and clinical application].

Nobuaki Suzuki1

  • 1Department of Transfusion Medicine, Nagoya University Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 1, 2025
PubMed
Summary
This summary is machine-generated.

Coagulation waveform analysis (CWA) offers a standardized method for evaluating blood clotting, surpassing traditional tests like rotational thromboelastometry (ROTEM). Our research developed a CWA-based diagnostic tool for dysfibrinogenemia, enhancing clinical diagnostics.

Keywords:
Clot waveform analysisCoagulation function testDysfibrinogenemia

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Area of Science:

  • Biochemistry
  • Hematology
  • Medical Diagnostics

Background:

  • Standardizing comprehensive blood coagulation function tests remains challenging, limiting their research application.
  • Rotational thromboelastometry (ROTEM) is a common clinical point-of-care test, but offers less usable data compared to other methods.
  • Existing coagulation tests often lack standardization and comprehensive data analysis capabilities.

Purpose of the Study:

  • To develop a novel diagnostic tool for dysfibrinogenemia utilizing coagulation waveform analysis (CWA).
  • To implement CWA for enhanced analysis of blood coagulation reactions.
  • To improve the standardization and data yield of blood coagulation testing.

Main Methods:

  • Coagulation waveform analysis (CWA) was employed to analyze changes in turbidity over time during fibrinogen-fibrin conversion.
  • A diagnostic tool was developed using CWA principles.
  • The developed CWA tool was implemented as an application on a Sysmex automated blood coagulation analyzer.

Main Results:

  • CWA provides more usable data compared to traditional methods like ROTEM.
  • The developed CWA-based diagnostic tool effectively analyzes coagulation reactions.
  • The implementation on an automated analyzer facilitates large-scale data collection and analysis.

Conclusions:

  • CWA offers a standardized and data-rich approach to blood coagulation analysis.
  • The developed diagnostic tool shows promise for identifying dysfibrinogenemia.
  • Automated analyzers integrated with CWA can significantly advance coagulation diagnostics.