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MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities

Chyntia Sherlyn Bunardi1, Minseo Yeom1, Prisca Kosasih2

  • 1Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, South Korea.

Experimental & Molecular Medicine
|October 1, 2025
PubMed

Insights

The MAP4K family of kinases regulates cell processes and is implicated in diseases like cancer. Targeting these MAP4K kinases shows promise for developing new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • The MAP4K family, comprising seven kinases (MAP4K1-7), is vital for cellular functions.
  • These kinases are involved in critical signaling pathways, including MAPK, JNK, and Hippo pathways.
  • Dysregulation of MAP4K signaling is linked to various diseases, notably cancer, autoimmune disorders, metabolic diseases, and neurodegenerative conditions.

Purpose of the Study:

  • To review the current understanding of individual MAP4K members' roles in cancer and other diseases.
  • To highlight the distinct and overlapping functions of MAP4K proteins within cellular signaling networks.
  • To discuss the therapeutic potential of targeting MAP4K family members for cancer treatment.

Main Methods:

  • Literature review of recent studies on MAP4K family.
  • Analysis of MAP4K involvement in key signaling pathways.
  • Examination of MAP4K roles in cancer development, progression, and immune modulation.

Main Results:

  • MAP4K proteins play significant roles in tumor growth, metastasis, and immune evasion.
  • Specific MAP4K members exhibit unique and shared functions in disease-related signaling.
  • Evidence suggests MAP4K pathways are critical in cancer pathogenesis.

Conclusions:

  • MAP4K family members are crucial regulators of cellular processes and disease development.
  • Targeting MAP4K kinases offers a promising therapeutic strategy for cancer and related diseases.
  • Further research is needed to elucidate specific molecular mechanisms and broaden therapeutic applications.

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