Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

444
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
444
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

664
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
664
Depression: Overview01:18

Depression: Overview

794
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
794
Physiology of Emotion01:20

Physiology of Emotion

3.2K
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
3.2K
Drive-Reduction Theory: Push Theory of Motivation01:27

Drive-Reduction Theory: Push Theory of Motivation

1.1K
Clark Hull's drive-reduction theory, introduced in the 1940s and 1950s and often termed the "push theory" of motivation, provides a framework for understanding how biological and learned drives influence behavior. Hull suggested that motivation originates from the need to alleviate physiological tension caused by unmet biological necessities. The theory proposes that when a basic need, such as hunger or sleep, goes unfulfilled, it creates an internal imbalance. This imbalance, or...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multisite Chronic Pain Reveals Neuro-Immune-Metabolic Dysregulation across Rheumatoid Arthritis and Depression.

Research (Washington, D.C.)·2026
Same author

Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.

Neuroscience bulletin·2026
Same author

The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease.

Science advances·2026
Same author

Homologous specialization of arcuate fasciculus ventrolateral frontal connectivity in marmosets and humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

MELK is Required for G2/M Phase Progression in Cortical Progenitors: Insights from Rare ASD-Associated Variants.

Cellular and molecular neurobiology·2026
Same author

NeuroMark-SZ: A Holistic Resting-State-fMRI-Based Model for Divergent Functional Circuitry in Schizophrenia.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 16, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.6K

Physical Activity and Depressive Mood Share the Structural Connectivity Between Motor and Reward Networks.

Shiqi Di1,2,3, Na Luo1,2, Weiyang Shi1,2

  • 1Beijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Neuroscience Bulletin
|October 1, 2025
PubMed
Summary

Regular exercise may alleviate depression by influencing brain connectivity. This study identified a specific structural connectivity pattern linked to physical activity and depression, offering insights into the biological mechanisms of exercise

Keywords:
Biological mechanismsDepressionPhysical activityReplicable associationStructural connectivity

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

907
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.5K

Related Experiment Videos

Last Updated: Jan 16, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.6K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

907
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Exercise is known to improve depressive symptoms.
  • The neural and biological mechanisms underlying this effect are not well understood.

Purpose of the Study:

  • To identify structural connectivity (SC) patterns associated with physical activity and depression.
  • To elucidate the biological underpinnings of exercise's antidepressant effects.

Main Methods:

  • Utilized a large neuroimaging cohort (UK Biobank, n=1,027) including individuals with major depressive disorder (MDD) and healthy controls (HCs).
  • Analyzed structural connectivity (SC) patterns and their correlation with physical activity, depressive mood, and group status.
  • Validated findings in an independent MDD dataset (n=3,496) and explored commonalities with bipolar disorder (n=81).

Main Results:

  • Identified a specific SC pattern linked to exercise, significantly correlated with depressive mood and differentiating MDDs from HCs.
  • This pattern was primarily located between motor and reward-related brain regions.
  • The SC pattern was associated with neurotransmitter receptors (serotonin, GABA) and enriched in synaptic signaling pathways and astrocyte cell types.

Conclusions:

  • A reproducible structural connectivity pattern links physical activity and depressive mood.
  • This pattern offers insights into the biological mechanisms by which exercise alleviates depression.
  • Findings may guide the development of novel neuromodulation targets for depression treatment.