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In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
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A potential imaging-based predictor for renal functional outcomes after partial nephrectomy for localized renal
Seong Min Ahn1, Dae Chul Jung2, Min Hoan Moon3
1Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.
BMC Urology
|October 2, 2025
Summary
Postoperative renal volume after partial nephrectomy (PN) is a significant predictor of chronic kidney disease (CKD) development. Early CT scans can help predict long-term CKD risk in patients with T1 renal cell carcinoma (RCC).
Area of Science:
- Nephrology
- Urology
- Radiology
Background:
- Partial nephrectomy (PN) is a standard treatment for T1 localized renal cell carcinoma (RCC).
- Assessing long-term renal function after PN is crucial for patient outcomes.
- Predictive factors for chronic kidney disease (CKD) development post-PN require further investigation.
Purpose of the Study:
- To evaluate if postoperative renal parenchymal volume, measured by CT, predicts long-term CKD development after PN.
- To identify significant prognostic factors for CKD following PN.
Main Methods:
- Retrospective analysis of 319 patients who underwent PN for T1 RCC.
- Kidney volumes were calculated using 3D rendering software from preoperative and first postoperative CT scans.
- Time-dependent Cox proportional-hazards regression was used to analyze risk factors for new-onset CKD.
Main Results:
- 4.0% of patients developed new-onset CKD at a median follow-up of 46 months.
- Univariate analysis identified age, hypertension, eGFR, and kidney volume/body weight as potential risk factors.
- Multivariable analysis confirmed that including total kidney volume improved model performance (p=0.008).
Conclusions:
- First postoperative CT-derived renal parenchymal volume is a significant risk factor for long-term CKD development after PN in T1 RCC patients.
- Postoperative imaging can aid in predicting CKD risk, assessing surgical success, and monitoring for recurrence or complications.
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