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Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study

  • 0Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Cardiovascular Diabetology +

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October 2, 2025

|

October 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The Triglyceride-glucose (TyG) index is linked to increased risks of major adverse cardiovascular events and death in patients after percutaneous coronary intervention (PCI). This index may serve as an early predictor for cardiovascular risk management.

Area Of Science

  • Cardiology
  • Metabolic Syndrome Research
  • Clinical Risk Prediction

Background

  • The Triglyceride-glucose (TyG) index is increasingly recognized for its association with coronary artery disease development and severity.
  • Its predictive value for adverse cardiovascular outcomes post-percutaneous coronary intervention (PCI) remains largely uninvestigated.

Purpose Of The Study

  • To evaluate the association between the TyG index and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) undergoing PCI.
  • To determine if the TyG index can serve as an early predictor of cardiovascular risk in this patient population.

Main Methods

  • A cohort of 8019 ACS patients who underwent PCI was analyzed from the COSTIC research.
  • Baseline clinical data and TyG index were collected; MACE (cardiovascular death, all-cause death, myocardial infarction, stroke) were the primary endpoints.
  • Multivariate Cox proportional hazards models and restricted cubic splines were used to assess the TyG index-outcome relationship.

Main Results

  • An elevated TyG index was significantly associated with increased risk of MACE, cardiovascular death, and all-cause death per interquartile range increment.
  • Stratified analyses revealed significant interactions between the TyG index and sex, smoking status, and ACS diagnosis.
  • No non-linear relationship was detected between the TyG index and cardiovascular outcomes via restricted cubic splines.

Conclusions

  • The TyG index is a significant predictor of adverse cardiovascular outcomes, including mortality, in ACS patients post-PCI.
  • The TyG index shows potential as an early risk stratification tool or a therapeutic target in managing cardiovascular disease.

Keywords:

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