Successful Management of a Rare Keratitis Caused by Mycobacterium Immunogenum After a Series of Misdiagnoses
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View abstract on PubMed
Summary
This summary is machine-generated.This case report highlights a rare Mycobacterium immunogenum keratitis diagnosis in an immunocompetent patient. Successful treatment involved 0.3% gatifloxacin eye gel, suggesting its efficacy for this challenging infection.
Area Of Science
- Ophthalmology
- Infectious Diseases
- Microbiology
Background
- Mycobacterium immunogenum keratitis is a rare ocular infection.
- It can be misdiagnosed and challenging to treat.
- This condition does not exclusively affect immunocompromised individuals.
Purpose Of The Study
- To report a case of successful diagnosis and management of Mycobacterium immunogenum keratitis.
- To highlight the diagnostic utility of metagenomic next-generation sequencing (mNGS).
- To evaluate treatment outcomes, particularly with 0.3% gatifloxacin eye gel.
Main Methods
- A case report of a 34-year-old immunocompetent female with a 6-month history of keratitis.
- Diagnostic workup included microbiological culture, acid-fast staining, and mNGS.
- Treatment involved topical amikacin, oral azithromycin, topical corticosteroids, and ultimately 0.3% gatifloxacin eye gel.
Main Results
- Mycobacterium immunogenum was identified as the causative agent.
- Initial treatments with amikacin and azithromycin were ineffective or toxic.
- Treatment with 0.3% gatifloxacin eye gel led to dramatic improvement and complete resolution within 4 months.
- Final visual acuity was 20/30 with mild residual scarring.
- The patient remained recurrence-free for 4 years.
Conclusions
- Mycobacterium immunogenum keratitis can occur in immunocompetent individuals without a history of trauma or surgery.
- mNGS is a valuable tool for rapid and accurate pathogen identification.
- 0.3% gatifloxacin eye gel appears to be an effective and safe treatment option for Mycobacterium immunogenum keratitis.
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