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Venous Thrombosis I: Introduction

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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Veins of Head and Neck

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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

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Neck-vein thrombosis during spaceflight.

Ulrich Limper^1,2, Jens Jordan^1,3

¹German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.

British Journal of Clinical Pharmacology

|October 2, 2025

Summary

Astronauts may face a risk of neck-vein thrombosis due to spaceflight conditions like weightlessness. Further research is crucial for effective prevention and treatment strategies during space missions.

Keywords:

Anticoagulants < Haematology Cardiovascular < Cardiology Haemostasis < Haematology Thrombosis < Haematology

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Area of Science:

Aerospace Medicine
Cardiovascular Physiology
Space Health

Background:

Spaceflight presents unique environmental stressors: weightlessness, radiation, and confinement.
These conditions can trigger unexpected health issues, including rare conditions like neck-vein thrombosis.

Purpose of the Study:

To investigate the occurrence and potential causes of neck-vein thrombosis in astronauts.
To assess the challenges in diagnosing and managing thromboembolic events during space missions.

Main Methods:

Review of recent cases of neck-vein thrombosis in astronauts on the International Space Station.
Analysis of retrospective studies for potential biomarkers of hypercoagulable states.
Examination of environmental factors (weightlessness, endothelial damage) and potential risk factors (oral contraceptives).

Main Results:

Neck-vein thrombosis has been incidentally detected in astronauts without obvious symptoms.
No consistent biomarkers for hypercoagulability in space have been identified.
Weightlessness-induced venous stasis and endothelial damage are potential contributing factors.

Conclusions:

Spaceflight-associated neck-vein thrombosis is a concern requiring further investigation.
Current diagnostic and treatment strategies for thrombosis in space are limited.
Enhanced surveillance and risk-mitigation strategies are essential for astronaut safety in future missions.