Multisystem Light Chain Amyloidosis: Diagnostic and Therapeutic Challenges.
Htet Zaw Lin1, Kay Kay Khaing Ko2, Thiraviyam Kandaswamy1
1Department of Nephrology, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, BRN.
Cureus
|October 2, 2025
Summary
Amyloid light chain (AL) amyloidosis is a rare disease causing organ damage. Early recognition is crucial for better outcomes in patients with unexplained nephrotic syndrome and heart failure.
Area of Science:
- Nephrology
- Cardiology
- Hematology
Background:
- Amyloid light (AL) chain amyloidosis is a rare, progressive multisystem disorder.
- It results from misfolded monoclonal light chain deposition, affecting organs like kidneys and heart.
- Prognosis depends on organ involvement and diagnostic timeliness.


