Related Experiment Video

Updated: Jan 16, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

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IQGAP1: cross-disease target via receptor-pathway networks

Shaopeng Zhu1,2, Yunpeng Zou1,2, Jie Guo2

  • 1School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in Oncology
|October 2, 2025
PubMed

Insights

IQGAP1 protein regulates cell functions and drives diseases like cancer and metabolic disorders. Targeting IQGAP1 offers potential for precision therapies in oncology, immunology, and metabolic conditions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • IQGAP1 is a scaffolding protein regulating cytoskeletal organization, cell motility, proliferation, and signaling.
  • IQGAP1 plays a critical role in malignancies, immune dysfunction, metabolic dysregulation, and cardiovascular diseases.
  • Dysregulation of IQGAP1 contributes to oncogenesis, immune evasion, metabolic imbalance, and chemoresistance.

Purpose of the Study:

  • To review advances in IQGAP1's structural domains.
  • To synthesize disease-specific signaling networks involving IQGAP1.
  • To explore therapeutic targeting strategies for IQGAP1.

Main Methods:

  • Literature review of IQGAP1's structure and function.
  • Analysis of signaling pathways modulated by IQGAP1 in various diseases.
  • Evaluation of current and emerging therapeutic strategies targeting IQGAP1.

Main Results:

  • IQGAP1's versatile binding capabilities enable modulation of key cellular processes.
  • IQGAP1 is implicated in diverse pathologies including cancer, metabolic syndromes, and immune disorders.
  • Targeting IQGAP1 demonstrates translational potential for precision medicine.

Conclusions:

  • IQGAP1 is a crucial regulator of cellular functions with significant implications in disease.
  • Understanding IQGAP1's role in disease-specific networks is key for therapeutic development.
  • IQGAP1 represents a promising target for precision therapies across multiple clinical domains.
Keywords:
IQGAP1cancercell signalingdrug resistanceimmune modulationmetabolic diseasesscaffold proteintherapeutic target

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