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Flavin-Containing Monooxygenase 3 Genetic Variants and Possible Susceptibility to Coronary Heart Disease Among Han

Yuanmin Mao1, Nan Gu1, Xiaowei Ma1

  • 1Department of Endocrinology, Peking University First Hospital, Beijing, China.

International Journal of Endocrinology
|October 2, 2025
PubMed

Insights

Flavin-containing monooxygenase 3 (FMO3) gene variants rs1800822 and rs909530 are linked to coronary heart disease (CHD) risk in Han Chinese with type 2 diabetes (T2D). Age influences the rs909530 association with CHD.

Area of Science:

  • Genetics and Cardiovascular Disease Research
  • Pharmacogenomics and Metabolic Disorders

Background:

  • Type 2 diabetes (T2D) significantly increases the risk of coronary heart disease (CHD).
  • Genetic factors, including single-nucleotide polymorphisms (SNPs), play a role in T2D complications like CHD.
  • Flavin-containing monooxygenase 3 (FMO3) is implicated in drug metabolism and may influence cardiovascular health.

Purpose of the Study:

  • To investigate the association between specific FMO3 gene SNPs and CHD risk in Han Chinese individuals with T2D.
  • To identify potential genetic markers for predicting CHD susceptibility in this population.
  • To explore gene-environment interactions, specifically gene-by-age, in relation to CHD risk.

Main Methods:

  • A case-control study involving 781 Han Chinese individuals with T2D (506 CHD cases, 275 controls).
  • Selection and genotyping of FMO3 tag-SNPs (rs2266780, rs1736557, rs1800822, rs909530) using mass spectrometry.
  • Statistical analysis using SPSS 25.0 to assess SNP associations with CHD risk, including gene-by-age interaction.

Main Results:

  • Lower frequencies of the rs1800822 T allele and rs909530 T allele were observed in the CHD group compared to controls (p=0.049 and p=0.029, respectively).
  • Carriers of the rs909530 CX genotype exhibited a significantly higher risk of non-premature CHD compared to TT genotype carriers (p < 0.001).
  • A significant gene-by-age interaction was detected for rs909530, indicating age modulates its effect on CHD risk.

Conclusions:

  • FMO3 gene SNPs rs1800822 and rs909530 are potentially associated with CHD risk in Han Chinese with T2D.
  • The rs909530 locus's influence on CHD risk is modulated by age.
  • Younger T2D patients with the rs909530 CX genotype may benefit from intensified cardiovascular risk factor management.

Keywords:
coronary heart diseaseflavin-containing monooxygenase 3single-nucleotide polymorphismstype 2 diabetes

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