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[Antibiotic sensitivity of the causative agents of suppurative surgical infection]
Abstract:
Sensitivity of 1492 strains of the causative agents of the surgical purulent infections, i. e. pathogenic Staphylococcus, Proteus, Ps. aeruginosa and E. coli to benzylpenicillin, streptomycin, levomycetin, tetracycline, erythromycin, oleandomycin, monomycin, kanamycin, novobiocin, ampicillin, oxacillin, ceporin, gentamicin and rifampicin was studied. Gentamicin was most active against all the bacterial species tested. The staphylococci were in addition sensitive in a high percentage of the cases to rifampicin, novobiocin, ceporin, monomycin and kanamycin. The isolates of E. coli were in addition sensitive to ceporin, monomycin and kanamycin. Sensitivity of the strains of Ps. aeruginosa and Proteus was low to all of the antibiotics except gentamycin. Most of the strains of the causative agents of the surgical purulent infections were multiresistant to 4 antibiotics. The number of the staphylococcal strains sensitive to benzylpenicillin, streptomycin and levomycetin increased in 1976 as compared to 1975 on the background of a limited use of these antibiotics in clinics.
Insights
Gentamicin demonstrated the highest activity against surgical infection pathogens, including Staphylococcus and E. coli. Increased sensitivity to older antibiotics like benzylpenicillin was observed in Staphylococcus strains.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Surgical site infections are frequently caused by pathogenic bacteria such as Staphylococcus, Proteus, Pseudomonas aeruginosa, and Escherichia coli.
- Understanding antibiotic susceptibility patterns is crucial for effective treatment and combating antimicrobial resistance.
Purpose of the Study:
- To evaluate the in vitro sensitivity of 1492 clinical isolates from surgical infections to a broad spectrum of antibiotics.
- To identify the most effective antibiotic agents against common causative agents of surgical purulent infections.
- To assess the prevalence of multidrug resistance among these bacterial pathogens.
Main Methods:
- Antibiotic susceptibility testing was performed on 1492 bacterial strains.
- Tested antibiotics included benzylpenicillin, streptomycin, levomycetin, tetracycline, erythromycin, oleandomycin, monomycin, kanamycin, novobiocin, ampicillin, oxacillin, ceporin, gentamicin, and rifampicin.
- Bacterial species included pathogenic Staphylococcus, Proteus, Pseudomonas aeruginosa, and Escherichia coli.
Main Results:
- Gentamicin exhibited the highest activity against all tested bacterial species.
- Staphylococcus strains showed high sensitivity to rifampicin, novobiocin, ceporin, monomycin, and kanamycin.
- E. coli isolates were also sensitive to ceporin, monomycin, and kanamycin.
- Pseudomonas aeruginosa and Proteus strains displayed low sensitivity to most antibiotics, with gentamicin being the exception.
- A significant proportion of isolates were multidrug-resistant, showing resistance to at least four antibiotics.
- A notable increase in Staphylococcus sensitivity to benzylpenicillin, streptomycin, and levomycetin was observed in 1976 compared to 1975, correlating with reduced clinical use of these agents.
Conclusions:
- Gentamicin is a highly effective antibiotic for treating surgical purulent infections caused by the studied pathogens.
- The emergence of multidrug resistance is a significant concern in surgical infections.
- Antibiotic stewardship, including the judicious use of older antibiotics, may contribute to restoring their efficacy, as suggested by the increased sensitivity of Staphylococcus strains to benzylpenicillin, streptomycin, and levomycetin.