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Updated: Jan 16, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Early recurrence of olfactory neuroblastoma: A case report and literature review
Alex Roman1,2, Moisés Augusto de Araújo2, Rudolfh Batista Arend3
1Federal University of the Southern Frontier, Rio Grande do Sul, Brazil.
Background:
Olfactory neuroblastoma (ONB) is a rare malignant tumor of the sinonasal cavity, often presenting with nonspecific symptoms and requiring complex multidisciplinary management.
Case Description:
A 55-year-old male developed progressive anosmia and recurrent epistaxis. Imaging revealed an invasive lesion involving the nasal cavity, paranasal sinuses, and intracranial space, along with cervical lymph node metastases. Diagnosis was confirmed histologically. Patient underwent craniofacial approach, cervical lymphadenectomy, and adjuvant radiotherapy. Despite aggressive treatment, early recurrence occurred in both nasal and intracranial compartments. With curative options exhausted, the patient was transitioned to palliative care.
Conclusion:
ONB has a high risk of recurrence, typically occurring years after initial treatment. However, early recurrence, as seen in this case, is rare and associated with aggressive tumor features such as high-grade histology and incomplete resection. These cases present significant therapeutic challenges and underscore the importance of close surveillance and further research into optimal management strategies for early recurrent ONB.
