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Updated: Jan 16, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Renal Cell Carcinoma With Myocardial Metastasis: A Case of Tumor-Induced Cardiac Tamponade After Radical Nephrectomy
Hussein Haidari1, Samuel C Hall2, Sagar Kumar3
1Department of Internal Medicine, University of South Alabama, Mobile, Alabama, USA.
Abstract:
Renal cell carcinoma (RCC) commonly metastasizes to the lung, bone, and liver. Cardiac metastasis, especially in the absence of IVC involvement, is considered extremely rare. We report an 81-year-old male with a history of clear cell RCC who underwent radical nephrectomy, and 10 years later, he presented with acute cardiac tamponade secondary to pathologically confirmed late myocardial metastasis.
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Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...