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Katja Sockel1, Christoph Röllig1, Anke Mütherig1

  • 1Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Dresden, Germany.

American Journal of Hematology
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DELTAelderly AMLeltrombopaghypomethylating therapythrombocytopenia

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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