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Published on: December 27, 2013
Attenuating amygdalin (vitamin B17) toxicity for potential therapeutic uses: insights into controlled release
Zubair Khalid Baig Moghal1, Rajesh Sreedharan Nair2, Saghir Akhtar3
1College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Introduction:
Amygdalin, is arguably, one of the most controversial molecules found in nature, with several therapeutic properties, including anticancer, but there are concerns over its toxicity in healthy tissue alike, which warrants a modified approach toward its utilization in therapy.
Areas Covered:
This review examines a rational approach toward its effective deployment in managing several diseases, anticancer, and anti-fibrotic, anti-inflammatory effects. The search for relevant articles was conducted by scouting the PubMed and Scopus on published articles from 2014-2025. We capture the key modulatory pathways of amygdalin that conveys several of its therapeutic effects and paradoxically, the observed toxicity in healthy tissue. The review contends that amygdalin remains as a formidable therapeutic contender for treating several diseases, if the dose can be attenuated through controlled release from nanotechnological-based formulation.
Expert Opinion:
Toxicity concerns and stability associated with amygdalin are best addressed through slow and controlled release from nano-encapsulation delivery systems. A further frontier can involve co or trio- nano-encapsulation of amygdalin with other therapeutic agents, whereby toxicity concerns and drug resistance are simultaneously addressed.
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