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Updated: Jan 16, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Photocatalytic Ring-Opening/1,3-Peroxyesterification of Arylcyclopropanes with Carboxylic Acids and tert-Butyl
Jun Pan1, Shujun Chen1, Leiyang Lv1
1Key Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.
Abstract:
Organic peroxides constitute a privileged family of O-O-containing compounds that serve as indispensable reagents or synthetic intermediates in industrial processes, pharmaceutical manufacturing, and polymer sciences. Herein, we disclose a photocatalytic ring-opening transformation of arylcyclopropanes with carboxylic acids and tert-butyl hydroperoxide, which enables the facile construction of structurally diverse 1,3-peroxyesterification products. This protocol proceeds under exceptionally mild, metal-free conditions with exquisite site-selectivity and broad functional-group tolerance. Besides, late-stage functionalization of bioactive molecules and downstream transformations are also performed.
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