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Reprimo (RPRM): A Tumor Suppressor That Induces Extrinsic Apoptosis via YAP Signaling

Masahiro Takikawa1,2, Rieko Ohki1

  • 1Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tokyo, Japan.

Cancer Science
|October 2, 2025
PubMed
Summary

Reprimo (RPRM) is a tumor suppressor. It has a novel extracellular function, acting as a ligand that triggers apoptosis by regulating the Hippo-YAP pathway, offering new cancer therapy potential.

Keywords:
Reprimoapoptosishippo pathwayp53tumor suppressor

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