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Managing leprosy reactions with secukinumab: Insights from a case series
Luciana Vilela Gomide1,2, João Paulo Turri Brufatto1, Thiago Jessé Kucarz1
1Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP, Brasil.
Background:
Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.
Methods:
We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.
Results:
Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.
Conclusions:
Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.
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