Related Experiment Video

Updated: Jan 16, 2026

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

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Epigenetic targeting in oral squamous cell carcinoma: mechanisms, therapies, and translational potential

Junting Yang1,2, Xiaoru Yan1,2, Xiaotang Wang1,2

  • 1Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Shanxi Medical University, Taiyuan, Shanxi, China.

Expert Review of Anticancer Therapy
|October 2, 2025
PubMed
Abstract

Insights

Epigenetic therapies, particularly those targeting noncoding RNAs (ncRNAs), show promise for oral squamous cell carcinoma (OSCC). Advanced delivery systems and combination strategies may improve treatment efficacy and patient outcomes.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Oral squamous cell carcinoma (OSCC) is a complex cancer with poor prognosis.
  • Epigenetic alterations like DNA methylation, histone modifications, and noncoding RNA (ncRNA) regulation drive OSCC progression.
  • These epigenetic changes offer potential therapeutic targets.

Purpose of the Study:

  • To review major epigenetic mechanisms in OSCC.
  • To highlight recent advances in epigenetic therapeutic agents and molecular targets for OSCC.
  • To discuss novel delivery strategies and clinical trial progress for OSCC epigenetic therapies.

Main Methods:

  • Comprehensive literature search of PubMed and ClinicalTrials.gov (January 2002 - July 2025).
  • Focus on ncRNA-based modulators (miRNAs, lncRNAs) and their roles in OSCC.
  • Analysis of innovative delivery systems (exosomes, nanoparticles) and clinical trial data.

Main Results:

  • ncRNA-based therapies are promising candidates for OSCC treatment.
  • Advanced delivery systems like exosomes and nanoparticles enhance specificity and overcome resistance.
  • An update on clinical trials targeting epigenetic regulators in OSCC is provided.

Conclusions:

  • Epigenetic therapies offer potential for precision treatment of OSCC.
  • Combination strategies and advanced delivery systems may accelerate clinical translation.
  • Biomarkers are crucial for early detection, risk stratification, and personalized OSCC therapy.
Keywords:
DNA methylationOSCCclinical translationdrug delivery systemsepigenetic therapyhistone modificationnoncoding RNAs

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