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Optical Contact Lenses Biosensors
Xiaoye Xia1, Yubing Hu1, Nan Jiang2,3
1Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2BU, U.K.
ACS Sensors
|October 2, 2025
Summary
Contact lens biosensors offer noninvasive monitoring of tear fluid biomarkers for early disease detection. Advances in materials and optical sensing enable real-time analysis for personalized healthcare.
Area of Science:
- Biomedical Engineering
- Ophthalmology
- Analytical Chemistry
Background:
- Tear fluid analysis offers noninvasive diagnostics for ocular and systemic health.
- Contact lens biosensors integrate optical sensing for real-time tear fluid monitoring.
Purpose of the Study:
- To review recent advances in contact lens biosensors for optical detection of tear-based biomarkers.
- To highlight the potential of these sensors in diagnosing and monitoring various diseases.
Main Methods:
- Utilizing biocompatible hydrogel and silicone hydrogel materials.
- Employing fabrication techniques like inkjet printing and 3D microfabrication.
- Integrating optical sensing mechanisms such as fluorescence and surface plasmon resonance.
Main Results:
- High sensitivity detection of glucose, lactate, electrolytes, cortisol, and inflammatory markers.
- Demonstrated potential in diagnosing diabetes, dry eye syndrome, and stress-related disorders.
- Identified challenges including background interference and multiplexed detection limitations.
Conclusions:
- Contact lens biosensors are a promising platform for personalized healthcare via noninvasive tear analysis.
- Future research should focus on robust chemistries, wireless readouts, and scalable manufacturing for clinical translation.
