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The Emory Treatment Resistance Interview for PTSD-Short Version (E-TRIP-S)
Boadie W Dunlop1,2, Nathaniel L Phillips3, Barbara O Rothbaum1
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
The Journal of Clinical Psychiatry
|October 2, 2025
Summary
A simplified scale, the Emory Treatment Resistance Interview for PTSD-Short version (E-TRIP-S), helps identify posttraumatic stress disorder (PTSD) treatment resistance. Many patients show limited benefit from prior therapies, but the E-TRIP-S may guide future treatment selection.
Area of Science:
- Psychiatry
- Clinical Psychology
- Medical Informatics
Background:
- Treatment resistance is common in posttraumatic stress disorder (PTSD).
- The Emory Treatment Resistance Interview for PTSD (E-TRIP) was previously developed to assess treatment resistance.
- A simplified version, the E-TRIP-Short (E-TRIP-S), was created to evaluate responses to first-line PTSD treatments.
Purpose of the Study:
- To introduce and validate the E-TRIP-Short (E-TRIP-S) as a simplified measure of treatment resistance in PTSD.
- To assess the preliminary utility of the E-TRIP-S in a US military population undergoing evaluation for PTSD treatment.
Main Methods:
- 102 US military personnel and veterans evaluated for PTSD were interviewed by trained assessors.
- The E-TRIP-S was administered to assess prior responses to evidence-based psychotherapies and medications.
- Descriptive statistics were used to analyze E-TRIP-S scores and evaluate the measure's utility.
Main Results:
- The majority of patients seeking intensive outpatient PTSD care showed elevated E-TRIP-S scores, indicating treatment resistance.
- Low percentages of patients reported significant benefit from prior psychotherapy (28.2%) or medication (23.2%) for PTSD symptoms.
- Approximately 25% of patients who did not benefit from one treatment modality reported significant benefit from the alternative modality.
Conclusions:
- The E-TRIP-S provides a simplified method for assessing treatment resistance in PTSD patients.
- Preliminary findings suggest the E-TRIP-S can inform clinical treatment selection and aid research by identifying treatment-resistant individuals for clinical trials.
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