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A versatile synthetic approach to various 5-alkynyl modified isatin derivatives: Cytotoxicity, acetylcholinesterase

Kirill P Cheremnykh1, Igor D Ivanov2, Mohammad S Hamad3

  • 1N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave, 9, 630090 Novosibirsk, Russian Federation; The Federal Research Center Insitute of Molecular Biology and Biophysics, 2/12, Timakov St., 630117 Novosibirsk, Russian Federation.

Bioorganic Chemistry
|October 2, 2025
PubMed

Keywords:
A3-coupling reactionsAcetylcholinesterase inhibitorsCytotoxicityIndole-1H-2,3-dioneIsatinMolecular docking studySonogashira reaction

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