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Published on: February 20, 2021
Antecedent traumatic injuries independently predict higher 90-day mortality for patients admitted to the ICU with
Courtney M Collins1, Anahita Jalilvand1, Whitney Kellett1
1The Ohio State University, Department of General Surgery, Suite 670 395 W. 12th Avenue, Columbus, OH, 43210-1267, USA.
Introduction:
Sepsis and trauma are leading causes of mortality. We hypothesize that antecedent trauma contributes to worse outcomes.
Methods:
A single-institution retrospective study of patients admitted to the SICU between September 2013-January 2019 who met Sepsis III criteria. 1401 patients were included, 7.8 % (n = 106) had preceding trauma. Cox regression was used to model in-hospital death and 90-day mortality. Kaplan-Meier 90- Day Survival Curve was calculated based on trauma status.
Results:
Antecedent trauma was associated with in-hospital mortality (p = 0.03). Trauma, transfer status, age, Charlson comorbidity index, admission lactate and SOFA score were all independent predictors of in-hospital and 90-day mortality (p < 0.005). 90-day survival curve showed a trend towards decreasing survival for the trauma cohort (p = 0.02).
Conclusion:
Our findings indicate antecedent trauma may have significant impact on patient outcomes. Further investigation is necessary to explore the underlying mechanisms linking trauma and sepsis.
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