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From genetic predisposition to mental health: Human cortical development in vitro
Arghya Mukherjee1, Pico Caroni2
1Center for Brain Research in Development, Genetics and Engineering, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Neuron
|October 2, 2025
Abstract
None:
In this issue of Neuron, Walsh et al.1 show how an improved human forebrain assembloid system that includes bona fide developing and differentiated cortical parvalbumin interneurons can be harnessed to investigate early human cortical development in genetic models of schizophrenia.
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