Targeting tumor-associated nerves enhances cancer immunotherapy
1Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Abstract:
Tumor-associated nerves actively shape tumor immunity. In a recent issue of Nature, Baruch et al.1 show that cancer-induced nerve injury drives T cell exhaustion and undermines PD-1 blockade. Targeting this neuro-immune crosstalk is a promising strategy to enhance cancer immunotherapy.
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