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Obstructive sleep apnea and associated mediators with left ventricular remodeling
Yingying Han1, Li Fu2, Xiaochen Jia2
1High-tech Zone Hospital of Qilu Hospital of Shandong University, Jinan, China.
Respiratory Medicine
|October 2, 2025
Summary
Obstructive sleep apnea (OSA) impacts cardiac remodeling, but not independently. Body mass index (BMI) and blood pressure significantly mediate this association, highlighting the need for weight and blood pressure management in OSA patients.
Area of Science:
- Cardiology
- Sleep Medicine
- Internal Medicine
Background:
- Conflicting evidence exists regarding the association between obstructive sleep apnea (OSA) and subclinical cardiac structural changes.
- Left ventricular remodeling (LVR) is a key cardiac structural change.
- Investigating the mediating factors of OSA's impact on cardiac structure is crucial.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea (OSA) and left ventricular remodeling (LVR).
- To explore the mediating roles of body mass index (BMI) and blood pressure in the OSA-LVR relationship.
Main Methods:
- Retrospective analysis of 518 patients with OSA.
- Regression models to assess the independent association of OSA with left ventricular hypertrophy (LVH).
- Mediation analysis to quantify the effect mediated by BMI and systolic blood pressure (SBP).
Main Results:
- Prevalence of LVH was 12.36%, with concentric remodeling being the most common pattern.
- Univariate analysis showed correlations between oxygen desaturation and LVR, but these were not independent in multivariate analysis.
- Mediation analysis indicated BMI accounted for 85.2% and SBP for 24.5% of the association between OSA severity (AHI) and LV mass.
Conclusions:
- The impact of OSA on LVR is predominantly mediated by BMI and, to a lesser extent, by systemic blood pressure.
- Findings emphasize the critical importance of weight management in OSA patients.
- Optimal blood pressure control is also highlighted as essential for mitigating cardiac remodeling in OSA.
Keywords:
Cardiovascular diseaseLeft ventricular hypertrophyMediation analysisObesityObstructive sleep apneaMore Related Videos
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