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Updated: Jan 16, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
Published on: April 11, 2018
Cystic Fibrosis (CF) and Modulators Based Therapy (CFTR) in oral and salivary perspectives: A single center
Sz Cofta1, E Paszynska2, M Roszak3
1Department of Pulmonology, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Objectives:
Recently introduced modulators-based therapy for cystic fibrosis (CF), provides new opportunity for better health outcomes and longer life. Single center cross-sectional aim of this study was to determine oral health status of adult CF patients, treated with CFTR modulators (CFTR-T), with no modulators (CFTR-0) in comparison to matched healthy individuals (Ctrl).
Materials And Methods:
Among 52 CF adult outpatients (male n = 24/female n = 28, 18-49y.) 34 were treated with triple-combination CFTR modulators (elexacaftor/tezacaftor/ivacaftor). Oral assessments included caries prevalence (Decayed, Missing, Filled teeth DMFT), dental hygiene (Plaque Control Record PCR), bleeding on probing (BOP), salivary mucins 5B/7, lysozyme, alpha-amylase (ELISA/PCR tests).
Results:
There was statistically significant difference between CF and Ctrl groups in decayed teeth (respectively median (min-max) 1 (0-12) vs. 0 (0-3) p < 0.001), PCR% (22.5 (0-100) vs. 10 (0-60) p < 0.001), BOP% (0 (0-39) vs. 0 (0-30) p < 0.006). Significantly higher concentrations of mucins 5b,7 and lysozyme (0.9 (0.3-20.9), 2.8 (0.9-12.8), 11.1 (5-31), all p < 0.001). In CFTR-T subgroup significantly higher dental plaque (31.5 (1-100) vs. 10 (0-60), p < 0.001) and lysozyme (8.8 (5-15.5), p < 0.001). Noteworthy, CFTR-T recipients gained weight (p = 0.002).
Conclusions:
Adult patients with CF showed higher susceptibility to dental caries, poorer oral hygiene and sustain proinflammatory status. However novel modulator therapy reduced the level of salivary mucins and enzymes.
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