Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

1.1K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bronchoscopic photodynamic therapy for endobronchial metastatic papillary thyroid carcinoma causing lobar airway obstruction: a case report.

Annals of translational medicine·2026
Same author

Phase 2 study of cabozantinib (XL184) with nivolumab and ipilimumab for the treatment of poorly differentiated neuroendocrine carcinomas (ETCTN10315).

The oncologist·2026
Same author

Molecular testing for the management of indeterminate thyroid nodules.

Endocrine-related cancer·2026
Same author

Immunotherapy in Initial Treatment of Anaplastic Thyroid Cancer: Evaluation of Overall Survival in a National Cancer Database Study.

Thyroid : official journal of the American Thyroid Association·2025
Same author

Appendiceal Neuroendocrine Tumors: Prognostic Role of Mesoappendiceal Invasion and Implications for Recommending Right Hemicolectomy versus Simple Appendectomy.

Annals of surgical oncology·2025
Same author

Risk of bowel ischemia in patients with mesenteric neuroendocrine tumors after treatment with <sup>177</sup>Lu-DOTATATE.

Endocrine oncology (Bristol, England)·2025

Related Experiment Video

Updated: Jan 16, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

937

Approach and Challenges for Patients With Advanced Radioiodine-Refractory Differentiated Thyroid Cancer.

Dipen C Patel1, Irina Azaryan2, Bhavana Konda1

  • 1Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|October 2, 2025
PubMed
Summary

Advanced radioactive iodine-refractory differentiated thyroid cancer (RAI-refractory DTC) presents a challenge. Systemic therapies offer improved disease control for patients with this advanced condition.

Keywords:
cabozantinibdifferentiated thyroid cancerlenvatinibmultikinase inhibitorsprecision oncologyradioiodine refractorysorafenibsystemic therapytargeted therapythyroid cancer

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.7K

Related Experiment Videos

Last Updated: Jan 16, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

937
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.7K

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Differentiated thyroid cancers (DTCs) typically have good prognoses with standard treatments like radioactive iodine (RAI).
  • A subset of DTC patients develop RAI-refractory disease, leading to progression and poorer outcomes despite conventional therapies.

Purpose of the Study:

  • To review current diagnostic, evaluative, and management strategies for advanced RAI-refractory DTC.
  • To summarize contemporary therapeutic approaches for this challenging subset of thyroid cancer patients.

Main Methods:

  • Consolidation of current evidence on advanced RAI-refractory DTC.
  • Exploration of pathophysiological basis, prognostic implications, and treatment selection strategies.

Main Results:

  • Systemic therapies, including antiangiogenic multikinase inhibitors and genotype-directed treatments, are transforming outcomes.
  • Treatment strategies encompass active surveillance, locoregional therapies, redifferentiation, and systemic approaches.

Conclusions:

  • Future directions include immunotherapy, novel agents, and personalized medicine.
  • Emphasis on precision oncology, toxicity management, and multidisciplinary care is crucial for optimizing patient outcomes.