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Association of IGF-1 with hypertension among children and adolescents

Zhenghao Zhao1, Ting Huang2, Pengzhe Xie3,4

  • 1Department of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, 22 Oixiangtai Road, Heping District, Tianjin, 300070, China.

BMC Pediatrics
|October 2, 2025
PubMed

Insights

Lower levels of Insulin-like Growth Factor 1 (IGF-1) are linked to a higher risk of hypertension in children and adolescents. This finding is crucial for understanding pediatric hypertension and its long-term health implications.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Health
  • Metabolic Disorders

Background:

  • Pediatric hypertension is a growing global concern with serious long-term health consequences.
  • Insulin-like Growth Factor 1 (IGF-1) plays a role in growth and metabolism, but its connection to childhood hypertension is unclear.

Purpose of the Study:

  • To investigate the association between Insulin-like Growth Factor 1 (IGF-1) levels and hypertension in pediatric populations.
  • To determine if IGF-1 levels can serve as a biomarker for hypertension risk in children and adolescents.

Main Methods:

  • A cohort of 586 children and adolescents was analyzed, categorized into normal and hypertension groups.
  • Logistic regression analysis was employed to assess the relationship between IGF-1 levels and hypertension risk.
  • Data included demographic, anthropometric, and laboratory parameters extracted from medical records.

Main Results:

  • A significant association was found between lower IGF-1 levels and an increased risk of hypertension.
  • Participants in the lowest quartile of IGF-1 had a significantly higher odds ratio for hypertension compared to the highest quartile.
  • This association was particularly notable in females, children aged 6-12 years, and those with abdominal obesity.

Conclusions:

  • Reduced IGF-1 levels are a significant risk factor for hypertension in children and adolescents.
  • The findings underscore the importance of monitoring IGF-1 levels, especially in at-risk pediatric subgroups.
  • Maintaining balanced IGF-1 levels is critical for pediatric hypertension management and long-term cardiovascular health.
Abstract

Keywords:
AdolescentChildrenHypertensionInsulin-like growth factor-1

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