Prevalence and risk factors for oral human papillomavirus and Epstein-Barr virus co-infections among sexually active males and females in Ibadan, Nigeria
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View abstract on PubMed
Summary
This summary is machine-generated.Oral Human papillomavirus (HPV) and Epstein-Barr virus (EBV) co-infection is prevalent in Nigeria, particularly in females. HIV status is a significant risk factor, necessitating targeted HPV vaccination programs.
Area Of Science
- Virology
- Oncology
- Public Health
Background
- Co-infection with Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) is linked to oral and oropharyngeal cancers.
- This study investigates the prevalence and risk factors of oral HPV and EBV co-infection in sexually active Nigerians.
Purpose Of The Study
- To determine the prevalence of oral HPV and EBV co-infection in a Nigerian population.
- To identify socio-demographic, behavioral, and biological risk factors associated with this co-infection.
Main Methods
- Secondary analysis of oral samples from the Sexual Behaviour and HPV Infection in Nigerians in Ibadan (SHINI) study.
- Real-time PCR was used for EBV DNA detection; HPV genotype data was retrieved from study records.
- Chi-square/Fisher exact tests and logistic regression models were employed to analyze associations and identify risk factors.
Main Results
- A prevalence of 26.9% for oral HPV and EBV co-infection was observed in 104 analyzed samples.
- Co-infection was predominantly found in females (96.4%).
- Significant associations were found with sex, anal HPV infection, genital HPV, and HIV status (p < 0.05).
Conclusions
- High prevalence of oral HPV and EBV co-infection exists in Nigerian males and females.
- HIV status emerged as a significant risk factor for this co-infection.
- Recommendations include targeted public health interventions, such as HPV vaccination programs for high-risk groups.
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