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Updated: Jan 16, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
The need for developing consensus-based guidelines in assessing Parkinson's disease laterality
Emily Houston1, Sean Boyd2, Vivikta Iyer1
1Binter Center for Parkinson's Disease & Movement Disorders, University of Vermont Medical Center University of Vermont Medical Center, USA; Department of Neurological Sciences, Larner College of Medicine, University of Vermont, USA.
Abstract:
This study investigated the correlation between Parkinson's disease laterality, as defined by the Hoehn and Yahr (HY) scale, and appendicular parkinsonism scores from the MDS-UPDRS Part III using the PPMI dataset. While most cases (89.6 %) showed congruence, a 10.4 % discordance suggests that factors beyond appendicular parkinsonism influence clinical HY staging, highlighting a need for standardized guidelines.
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