YAP Expression Confers Therapeutic Vulnerability to Cuproptosis in Breast Cancer Cells by Regulating Copper Homeostasis
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View abstract on PubMed
Summary
This summary is machine-generated.Yes-associated protein (YAP) expression increases cancer cells' vulnerability to cuproptosis, a copper-related cell death. Targeting YAP with melatonin and a novel nanomaterial effectively suppressed tumor growth and metastasis.
Area Of Science
- Oncology
- Molecular Biology
- Nanotechnology
Background
- Copper metabolism is crucial in cancer progression, presenting a therapeutic target.
- Effective diagnostic markers and personalized treatments for copper-targeted cancer therapy are lacking.
Purpose Of The Study
- To investigate the role of Yes-associated protein (YAP) in cuproptosis.
- To develop novel therapeutic strategies for copper-targeting cancer therapy.
Main Methods
- Molecular analyses to assess YAP inhibition effects on cuproptosis and copper homeostasis.
- Investigated melatonin's impact on YAP signaling and copper metabolism genes.
- Developed and evaluated a functional nanomaterial (EsMP@Fu) for targeted cancer therapy.
Main Results
- YAP expression confers susceptibility to cuproptosis; YAP inhibition abolishes cuproptotic characteristics.
- YAP regulates the copper chaperone ATOX1; its overexpression restores cuproptosis sensitivity.
- Melatonin inhibits YAP signaling, reducing copper metabolism gene expression.
- EsMP@Fu significantly suppressed tumor growth by 60% in vivo, reduced metastasis, and induced antitumor immunity.
Conclusions
- YAP overexpression sensitizes cancer cells to cuproptosis, indicating therapeutic vulnerability.
- Targeting YAP signaling with agents like melatonin and novel nanomaterials offers a promising precision medicine strategy for copper-based cancer therapy.
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