Related Experiment Video

Updated: Jan 16, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

8.4K

Integrative Network Pharmacology and Proteomics Decipher the Immunomodulatory Mechanism of Sulforaphane Against

Xin Du1, Xingyu Yang1, Chenchen Zhang1

  • 1Department of Dermatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Molecular Nutrition & Food Research
|October 3, 2025
PubMed

Insights

Sulforaphane (SFN) effectively combats intrinsic skin aging by improving skin structure and immune function. This natural compound activates the apelin signaling pathway, offering new therapeutic targets for age-related skin changes.

Area of Science:

  • Dermatology and aging research
  • Molecular biology and pharmacology
  • Immunology

Background:

  • Intrinsic skin aging involves structural decline and frailty.
  • Sulforaphane (SFN), an anti-inflammatory compound, shows potential beyond cancer therapy.
  • The role of SFN in intrinsic skin aging requires elucidation.

Purpose of the Study:

  • To investigate the mechanisms of SFN in intrinsic skin aging.
  • To identify SFN's anti-aging targets and pathways.
  • To evaluate SFN's effects on skin structure and immune function in aging mice.

Main Methods:

  • Integrative network pharmacology and proteomics were employed.
  • An 18-month-old natural aging mouse model was used.
  • SFN supplementation effects were assessed via skin analysis, proteomics, and immune cell profiling.

Main Results:

  • SFN supplementation alleviated skin structure, redox homeostasis, and immune cell composition.
  • Proteomic analysis revealed SFN reversed aging-associated protein expression changes.
  • SFN upregulated proteins enriched in the apelin signaling pathway, rescuing T cell depletion.

Conclusions:

  • SFN improves skin morphology and immune functions by activating the apelin signaling pathway.
  • SFN demonstrates significant potential in counteracting intrinsic skin aging.
  • The apelin signaling pathway represents a key target for SFN's anti-aging effects in skin.
Keywords:
apelin signaling pathwaycell senescenceintrinsic skin agingnetwork pharmacologyproteomicssulforaphane

More Related Videos

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

1.2K
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

526

Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.6K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
228