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Vaccinations01:51

Vaccinations

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Operationalizing African self-reliance in vaccine manufacturing.

Chiluba Mwila1, Anna Mia Ekström2,3, Beate Kampmann4

  • 1Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia.

Global Health Action
|October 3, 2025
PubMed
Summary

Africa aims for 60% local vaccine production by 2040 to enhance health security. Achieving this requires addressing ecosystem gaps in R&D, workforce, technology transfer, regulation, and market creation.

Keywords:
Africa CDCAfrican Pooled Procurement Mechanism (APPM)Framework for Action (FFA)Platform for Harmonized African Health Products Manufacturing (PHAHM)vaccine production

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Area of Science:

  • Global Health
  • Vaccine Manufacturing
  • Health Security

Background:

  • COVID-19 highlighted Africa's vulnerability in vaccine security.
  • African Union and Africa CDC initiated the Framework for Action (FFA) for local vaccine production.
  • Goal: Achieve 60% local vaccine production by 2040.

Purpose of the Study:

  • Discuss strategies to advance Africa's vaccine manufacturing agenda.
  • Identify and address critical gaps in the African health product manufacturing ecosystem.
  • Conclude on necessary actions for sustainable vaccine security.

Main Methods:

  • Organized a 2024 seminar series with multidisciplinary international experts.
  • Facilitated discussions on research and development (R&D), workforce, technology transfer, regulatory systems, demand creation, and coordination.
  • Synthesized expert insights on achieving local vaccine production goals.

Main Results:

  • Achieving vaccine self-reliance necessitates a comprehensive ecosystem approach.
  • Key areas for strengthening include R&D investment, capacity building, equitable partnerships, and skilled workforce development.
  • Robust regulatory frameworks, technology transfer support, market shaping, and coordination are crucial.

Conclusions:

  • Strategic investments and policy support are vital for Africa's vaccine manufacturing aspirations.
  • Strengthening R&D, workforce, technology transfer, regulation, and market demand are essential.
  • Coordinated efforts are needed for optimized resource allocation and sustainable health security.