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Updated: Jan 16, 2026
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
3D-printed biopolymer-based microneedle for enhanced photodynamic therapy in melanoma treatment
Aishat Adejoke Obalola1, Heidi Abrahamse1, Sathish Sundar Dhilip Kumar1
1Laser Research Centre, University of Johannesburg, Johannesburg, South Africa.
Abstract:
Melanoma is a highly aggressive cancer with poor prognosis and resistance to many treatments, especially after metastasis. Developing new preventive and adjuvant therapies is critical for improving melanoma outcomes. Photodynamic therapy (PDT) has shown potential in selectively targeting malignant cells while minimizing damage to healthy tissue. However, improving the delivery of photosensitizers (PS) to melanoma cells while reducing systemic toxicity remains a challenge. Microneedles, a transcutaneous drug delivery method, offer advantages such as better patient compliance and easier management compared to traditional methods like intramuscular or intravenous injection. Despite these benefits, manufacturing precise microneedles remains a hurdle. Recent research has focused on 3D printing techniques for creating transdermal drug delivery devices, including microneedles. This review summarizes recent advantages in 3D printed biopolymer-based drug delivery systems using microneedles, evaluates their potential, and discusses the challenges and future prospects of 3D printing in transdermal therapy.
Insights
Developing new melanoma treatments is crucial. This review explores 3D printed microneedles for photodynamic therapy (PDT) delivery, aiming to improve melanoma treatment and reduce side effects.
Area of Science:
- Oncology
- Biomaterials Science
- Drug Delivery Systems
Background:
- Melanoma is an aggressive cancer with poor treatment outcomes, especially upon metastasis.
- Photodynamic therapy (PDT) shows promise for selective cancer targeting but faces challenges in photosensitizer delivery and systemic toxicity.
- Current drug delivery methods for melanoma have limitations, necessitating innovative approaches.
Purpose of the Study:
- To review advancements in 3D printed biopolymer-based microneedle systems for transdermal drug delivery.
- To evaluate the potential of these microneedle systems for melanoma treatment, particularly for photodynamic therapy.
- To discuss the challenges and future directions for 3D printing in transdermal melanoma therapy.
Main Methods:
- Review of recent scientific literature on 3D printing techniques for microneedle fabrication.
- Analysis of biopolymer materials used in 3D printed microneedles for drug delivery.
- Evaluation of studies investigating microneedle-based transdermal delivery of photosensitizers for melanoma.
Main Results:
- 3D printing offers a promising method for precise and customizable microneedle manufacturing.
- Biopolymer-based microneedles demonstrate potential for enhanced transdermal delivery of therapeutic agents.
- Microneedle technology, particularly when 3D printed, can improve patient compliance and drug targeting for melanoma treatment.
Conclusions:
- 3D printed microneedles represent a significant advancement in transdermal drug delivery for melanoma.
- This technology holds potential for improving the efficacy of photodynamic therapy by optimizing photosensitizer delivery.
- Further research and development are needed to overcome manufacturing challenges and fully realize the clinical potential of 3D printed microneedles in melanoma therapy.
