Ectopic breast fibroadenoma of the vulva: a case report

Vulvar ectopic breast fibroadenoma (EBF) is an exceptionally rare benign neoplasm that lacks distinctive clinical or radiological features rendering pre-operative differentiation from other vulvar masses challenging. Definitive diagnosis requires histopathological confirmation. Two non-exclusive histogenetic hypotheses have been proposed: (1) derivation from ectopic breast tissue along the embryonic "milk line," (2) origin from hormonally responsive anogenital mammary-like glands with latent potential for benign or malignant transformation.

A 41-year-old woman presented with an incidentally discovered, slowly enlarging, painless right vulvar mass. Ultrasonography revealed a well-circumscribed hypoechoic nodule. Complete surgical excision was performed, and histopathological evaluation-including immunohistochemistry for estrogen receptor, progesterone receptor, GATA3, and p63-confirmed ectopic breast fibroadenoma. No recurrence was detected at 3-month follow-up.

Despite its rarity, vulvar EBF must be considered in the differential diagnosis of vulvar masses in reproductive-age women. En-bloc excision is curative; however, long-term surveillance is warranted to monitor for hormone-driven recurrence or malignant evolution.