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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Understanding Cancer-Related Pain: Pathophysiology, Classification, and Treatment Modalities.

Jerish Murari1, Ish Sharma2, Siddharth Arjun Atwal3

  • 1Department of General Medicine, Chettinad Hospital and Research Institute, Kelambakkam, IND.

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Cancer-related pain management requires a mechanism-based, multidisciplinary approach. Integrating pharmacologic, psychosocial, and emerging digital health strategies improves patient quality of life and treatment adherence.

Keywords:
artificial intelligencecancer-related painmechanism-based treatmentprecision oncologytranslational pain research

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Area of Science:

  • Oncology
  • Pain Medicine
  • Clinical Pharmacology

Background:

  • Cancer-related pain (CRP) significantly impacts patient quality of life, psychological well-being, and treatment adherence.
  • Understanding the complex pathophysiology of CRP, including nociceptive and neuropathic mechanisms, is crucial for effective management.

Purpose of the Study:

  • To synthesize current knowledge on CRP pathophysiology, classification, and multidisciplinary management.
  • To provide clinical insights and identify research priorities for optimizing cancer pain control.

Main Methods:

  • Narrative, mechanism-informed review of existing literature and clinical frameworks.
  • Appraisal of major classification systems (e.g., WHO analgesic ladder, ICD-11, ECI) and assessment tools (e.g., VAS, BPI, HADS).

Main Results:

  • A flexible, mechanism-based, multimodal management model integrating pharmacologic, adjuvant, interventional, and psychosocial approaches is recommended.
  • Established evidence supports opioid pharmacotherapy and cognitive behavioral therapy; complementary modalities require further high-quality trials.
  • Emerging innovations like AI-driven monitoring and pharmacogenomics show promise but need further validation.

Conclusions:

  • Adopting mechanism-based classification and fostering multidisciplinary collaboration are key actionable priorities.
  • Expanding multimodal pain management access in low-resource settings and rigorously validating new technologies are essential for advancing cancer care.