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Related Experiment Video

Updated: Jan 16, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
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Association Between Gut-Brain Axis Dysfunction and Vestibular Migraine Severity.

Muhammad Alryan Masood1, Namra Asif2, Muhibullah Younus3

  • 1Stroke Medicine, University Hospital of Wales, Cardiff, GBR.

Cureus
|October 3, 2025
PubMed
Summary

Gut-brain axis dysfunction is linked to increased vestibular migraine severity in Pakistan. Gastrointestinal symptoms and psychological factors are key indicators for managing this condition.

Keywords:
gastrointestinal symptomsgut-brain axismigraine disabilityvertigovestibular migraine

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Migraine Research

Background:

  • Vestibular migraine (VM) involves vertigo and migraine symptoms.
  • The gut-brain axis (GBA) role in VM severity is unclear, especially in Pakistan.
  • This study investigates the GBA-VM severity link.

Purpose of the Study:

  • To elucidate the relationship between gut-brain axis dysfunction and vestibular migraine severity.
  • To identify predictors of VM severity in a Pakistani population.

Main Methods:

  • Cross-sectional study of 386 VM patients at Jinnah Hospital, Lahore.
  • Utilized GSRS, MIDAS, and VSS-SF questionnaires.
  • Employed correlation and regression analyses to assess GBA dysfunction and VM severity.

Main Results:

  • Significant positive correlations found between gastrointestinal symptoms, migraine disability, and vertigo severity (P < 0.001).
  • Gastrointestinal symptom severity, older age, and vertigo incidence predicted increased VM disability and vertigo severity (P < 0.05).
  • Anxiety and depression were associated with severe symptoms, suggesting a link to GBA dysfunction.

Conclusions:

  • GBA-related symptoms are associated with greater VM severity.
  • Assessing gastrointestinal and psychological comorbidities is crucial for VM management in Pakistan.
  • Future research should explore gut-targeted interventions.