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Non-invasive Reversible Software-based Configuration of a Clinically Used Linear Accelerator for Preclinical Electron

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    Area of Science:

    • Medical Physics
    • Radiation Oncology
    • Preclinical Research

    Background:

    • Clinical linear accelerators (linacs) require invasive modifications for ultra-high dose rate (UHDR) electron experiments.
    • Limited accessibility hinders broader implementation of UHDR preclinical research.

    Purpose of the Study:

    • To develop and validate a non-invasive software-based method for configuring a clinical TrueBeam linac for UHDR electron delivery.
    • To enable reversible switching between UHDR and conventional (CONV) modes on a clinical linac.

    Main Methods:

    • Utilized service mode software with modified RF and beam current settings.
    • Retracted photon target/monitor chamber; inserted a low-energy scattering foil.
    • Employed external AC current transformer (ACCT) for monitoring, custom collimator, and ion chamber for dose calibration and reproducibility testing.

    Main Results:

    • Achieved accurate and reproducible UHDR electron delivery (12.8 MeV) with dose-per-pulse exceeding 0.5 Gy.
    • Maintained beam quality, including percent depth dose (PDD) and field profiles comparable to CONV mode (11.9 MeV).
    • Demonstrated output variation <4% and strong detector linearity.

    Conclusions:

    • Successfully implemented a non-invasive UHDR electron configuration on a clinical TrueBeam linac.
    • This method facilitates preclinical FLASH research using widely available clinical equipment.
    • Eliminates the need for hardware manipulation, increasing accessibility for UHDR studies.