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Related Experiment Video

Updated: Jan 16, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Achieving handle-level random access in an encrypted DNA archival storage system via frequency dictionary mapping

Ben Cao¹, Xue Li^2,3, Bin Wang³

¹School of Computer Science and Technology, Dalian University of Technology, Dalian 116024, China.

Patterns (New York, N.Y.)

|October 3, 2025

Summary

This study introduces frequency dictionary mapping coding (FDMC) for DNA data storage, enabling random access and enhancing security. The new method ensures data integrity and boosts DNA storage

Keywords:

DNA storage data security frequency dictionary mapping coding random access

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Last Updated: Jan 16, 2026

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Area of Science:

Biotechnology
Data Storage
Bioinformatics

Background:

DNA storage offers high density and durability but suffers from slow access and security issues.
Current DNA data archival systems lack efficient random access capabilities.
Data security and integrity are critical concerns for long-term DNA storage.

Purpose of the Study:

To develop a novel coding method for DNA archival storage enabling handle-level random access.
To enhance data security and integrity in DNA storage systems.
To bridge the gap between DNA storage and traditional storage modes.

Main Methods:

Frequency Dictionary Mapping Coding (FDMC) was proposed for handle-level random access.
A hybrid e-molecular encryption strategy was implemented for data security.
A multi-level error-correction algorithm was introduced to ensure data integrity.

Main Results:

FDMC enabled lossless encrypted DNA storage with handle-level random access.
The system demonstrated a balance between security and robustness.
91.74% data recovery was achieved even with a 10% loss of DNA sequences.
A storage density exceeding 1.80 bits per nucleotide was maintained.

Conclusions:

FDMC significantly enhances the application potential of DNA as a storage medium.
The developed system addresses key limitations of current DNA storage technologies.
This approach facilitates the integration of DNA storage with conventional storage systems.