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Choroidal Vascularity Index Changes in Treatment-Naïve Hypercholesterolemia Patients

Zeynep Eylul Ercan1, Mucahit Yetim2, Selim Cevher3

  • 1Department of Ophthalmology, Yenimahalle Education and Training Hospital, Yildirim Beyazit University, Ankara, Turkey.

Journal of Current Ophthalmology
|October 3, 2025
PubMed

Insights

Newly diagnosed hypercholesterolemia patients show a lower choroidal vascularity index (CVI) and thicker stromal area compared to healthy individuals. Lipid levels did not correlate with CVI in this study.

Area of Science:

  • Ophthalmology
  • Cardiovascular Health
  • Medical Imaging

Background:

  • Hypercholesterolemia is a significant risk factor for cardiovascular disease.
  • Choroidal vascularity index (CVI) is a measure of vascular status in the choroid.
  • The impact of hypercholesterolemia on choroidal vascularity is not well understood.

Purpose of the Study:

  • To investigate the choroidal vascularity index (CVI) in newly diagnosed hypercholesterolemia patients.
  • To compare CVI between hypercholesterolemia patients and healthy controls.
  • To explore the relationship between lipid levels and CVI.

Main Methods:

  • Cross-sectional study comparing 50 hypercholesterolemia patients and 50 controls.
  • Analysis of choroidal vascularity index (CVI), total choroidal area (TCA), luminal area (LA), and stromal area (SA).
  • Statistical analysis included analysis of covariance and partial correlation, adjusting for age, sex, and axial length.

Main Results:

  • Choroidal vascularity index (CVI) was significantly lower in hypercholesterolemia patients (P < 0.001).
  • Stromal area (SA) was significantly thicker in patients (P = 0.006), while TCA and LA showed no significant differences.
  • No correlation was found between lipid levels and CVI.

Conclusions:

  • Hypercholesterolemia is associated with a reduced CVI and increased stromal area in the choroid.
  • The observed changes in stromal area did not affect overall choroidal area or luminal area.
  • Further research with longer follow-up is needed to elucidate the effects of increased stromal area.
Abstract

Keywords:
AtherosclerosisChoroidChoroidal vascularity indexHypercholesterolemiaLipoproteins

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