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Clindamycin-Induced Dermatitis and the Sparing Phenomenon: A Case Report.
Noah Gordon1, Michelle Zydeck1, Ruba Odeh2
1Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, USA.
Cureus
|October 3, 2025
Summary
Drug-induced dermatitis, a T-cell reaction, can present with a rash sparing recent skin infections. This case shows clindamycin-induced rash avoiding a Pasteurella multocida cellulitis site.
Area of Science:
- Immunodermatology
- Clinical Case Reports
- Hypersensitivity Reactions
Background:
- Drug-induced dermatitis is a T-cell-mediated hypersensitivity.
- The sparing phenomenon, where rash avoids recent skin disease, is rare.
- Understanding local immune responses in drug reactions is crucial.

