Guillain-Barré Syndrome Mimicking Autoimmune Hepatitis: A Rare Entity

This case report describes a rare association between autoimmune hepatitis (AIH) and Guillain-Barré syndrome. A 71-year-old woman with a history of hypertension, diabetes, and hyperlipidemia presented with elevated liver enzymes and progressive distal limb weakness. Electromyography confirmed acute motor axonal neuropathy, a variant of Guillain-Barré syndrome, without an identifiable trigger. Serologies for viral hepatitis were negative; however, autoantibodies, including antinuclear antibody, antimitochondrial antibody, and smooth muscle antibody, were positive. Liver biopsy demonstrated histopathologic features consistent with AIH, although typical clinical symptoms of AIH were not apparent. The patient's liver enzymes normalized after treatment with intravenous immunoglobulin. Further investigation into this uncommon clinical association is warranted.