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Updated: Jan 16, 2026
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
The influence of targeted therapies in the inner ear
Tony Bonilla1, Jake DiFatta2, Esperanza Bas Infante3
1Neuroscience Program, Howard College of Arts and Sciences, Samford University, Homewood, AL, United States.
Abstract:
Scientific research has significantly propelled advancements in healthcare. One notable application is precision medicine, which seeks to analyze and comprehend disease pathology to offer personalized medical treatments to patients. Targeted oncology, a branch of precision medicine, focuses on identifying and targeting specific molecules that regulate cancer cells, thereby minimizing harm to healthy cells. Different types of targeted therapy against cancer include monoclonal antibodies and small molecules. This manuscript intends to provide an overview of the influence of these targeted oncology and non-oncology therapies on hearing. Furthermore, side effects including immune-related adverse events will be reviewed as potential causes of hearing deterioration in this patient population.
Insights
Precision medicine advances healthcare through personalized treatments. This review examines how targeted oncology therapies and other treatments impact hearing, including potential immune-related side effects.
Area of Science:
- Healthcare advancements
- Precision medicine
- Oncology
Background:
- Precision medicine offers personalized treatments by analyzing disease pathology.
- Targeted oncology identifies and targets cancer cell-specific molecules.
- Targeted therapies include monoclonal antibodies and small molecules.
Purpose of the Study:
- To provide an overview of the influence of targeted oncology and non-oncology therapies on hearing.
- To review potential causes of hearing deterioration in patients receiving these therapies.
- To examine immune-related adverse events as a cause of hearing loss.
Main Methods:
- Literature review of targeted oncology and non-oncology therapies.
- Analysis of mechanisms influencing hearing.
- Review of immune-related adverse events and their ototoxic potential.
Main Results:
- Targeted therapies can impact hearing function.
- Immune-related adverse events are associated with hearing deterioration.
- Ototoxicity is a significant concern in patients undergoing targeted treatments.
Conclusions:
- Understanding the ototoxic effects of targeted therapies is crucial for patient care.
- Monitoring hearing function in patients receiving targeted treatments is recommended.
- Further research is needed to mitigate hearing loss associated with cancer therapies.
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