Related Experiment Video
Updated: Jan 16, 2026

09:26
Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis
Published on: March 23, 2021
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Low-Input Assay for Transposase-Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate
Kevin Schmid1, Robin P Schenk1, Gabriela M Wiedemann1
1Clinical Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Munich, Bavaria, Germany.
European Journal of Immunology
|October 3, 2025
Abstract
None:
Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

